Anti-infective immunoadhesins from plants.
Identifieur interne : 001892 ( Main/Exploration ); précédent : 001891; suivant : 001893Anti-infective immunoadhesins from plants.
Auteurs : Keith Wycoff [États-Unis] ; James Maclean [États-Unis] ; Archana Belle [États-Unis] ; Lloyd Yu [États-Unis] ; Y. Tran [États-Unis] ; Chad Roy [États-Unis] ; Frederick Hayden [États-Unis]Source :
- Plant biotechnology journal [ 1467-7652 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Plantes.
- traitement médicamenteux : Maladies transmissibles.
- usage thérapeutique : Fragments Fc des immunoglobulines.
- Animaux, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Immunoglobulin Fc Fragments.
- drug therapy : Communicable Diseases.
- metabolism : Plants.
- Animals, Humans.
Abstract
Immunoadhesins are recombinant proteins that combine the ligand-binding region of a receptor or adhesion molecule with immunoglobulin constant domains. All FDA-approved immunoadhesins are designed to modulate the interaction of a human receptor with its normal ligand, such as Etanercept (Enbrel(®) ), which interferes with the binding of tumour necrosis factor (TNF) to the TNF-alpha receptor and is used to treat inflammatory diseases such as rheumatoid arthritis. Like antibodies, immunoadhesins have long circulating half-lives, are readily purified by affinity-based methods and have the avidity advantages conferred by bivalency. Immunoadhesins that incorporate normal cellular receptors for viruses or bacterial toxins hold great, but as yet unrealized, potential for treating infectious disease. As decoy receptors, immunoadhesins have potential advantages over pathogen-targeted monoclonal antibodies. Planet Biotechnology has specialized in developing anti-infective immunoadhesins using plant expression systems. An immunoadhesin incorporating the cellular receptor for anthrax toxin, CMG2, potently blocks toxin activity in vitro and protects animals against inhalational anthrax. An immunoadhesin based on the receptor for human rhinovirus, ICAM-1, potently blocks infection of human cells by one of the major causes of the common cold. An immunoadhesin targeting the MERS coronavirus is in an early stage of development. We describe here the unique challenges involved in designing and developing immunoadhesins targeting infectious diseases in the hope of inspiring further research into this promising class of drugs.
DOI: 10.1111/pbi.12441
PubMed: 26242703
Affiliations:
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All FDA-approved immunoadhesins are designed to modulate the interaction of a human receptor with its normal ligand, such as Etanercept (Enbrel(®) ), which interferes with the binding of tumour necrosis factor (TNF) to the TNF-alpha receptor and is used to treat inflammatory diseases such as rheumatoid arthritis. Like antibodies, immunoadhesins have long circulating half-lives, are readily purified by affinity-based methods and have the avidity advantages conferred by bivalency. Immunoadhesins that incorporate normal cellular receptors for viruses or bacterial toxins hold great, but as yet unrealized, potential for treating infectious disease. As decoy receptors, immunoadhesins have potential advantages over pathogen-targeted monoclonal antibodies. Planet Biotechnology has specialized in developing anti-infective immunoadhesins using plant expression systems. An immunoadhesin incorporating the cellular receptor for anthrax toxin, CMG2, potently blocks toxin activity in vitro and protects animals against inhalational anthrax. An immunoadhesin based on the receptor for human rhinovirus, ICAM-1, potently blocks infection of human cells by one of the major causes of the common cold. An immunoadhesin targeting the MERS coronavirus is in an early stage of development. We describe here the unique challenges involved in designing and developing immunoadhesins targeting infectious diseases in the hope of inspiring further research into this promising class of drugs.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Louisiane</li><li>Virginie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Wycoff, Keith" sort="Wycoff, Keith" uniqKey="Wycoff K" first="Keith" last="Wycoff">Keith Wycoff</name></region><name sortKey="Belle, Archana" sort="Belle, Archana" uniqKey="Belle A" first="Archana" last="Belle">Archana Belle</name><name sortKey="Hayden, Frederick" sort="Hayden, Frederick" uniqKey="Hayden F" first="Frederick" last="Hayden">Frederick Hayden</name><name sortKey="Maclean, James" sort="Maclean, James" uniqKey="Maclean J" first="James" last="Maclean">James Maclean</name><name sortKey="Roy, Chad" sort="Roy, Chad" uniqKey="Roy C" first="Chad" last="Roy">Chad Roy</name><name sortKey="Tran, Y" sort="Tran, Y" uniqKey="Tran Y" first="Y" last="Tran">Y. Tran</name><name sortKey="Yu, Lloyd" sort="Yu, Lloyd" uniqKey="Yu L" first="Lloyd" last="Yu">Lloyd Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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